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Table 4 Association of miRNA expression levels with clinical variables

From: Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism

Variable

let-7a

let-7d

let-7f

miR-16

miR-29b

miR-142-3p

miR-144

miR-223

miR-203

miR-1275

Age (in yrs.)

          

<60

0.49 ± 0.22

0.44 (0.11–1.25)

0.51 (0.2–1.25)

0.6 (0.01–1.45)

1.58 (0.02–7.79)

5.76 (0.07–39.44)

10.05 ± 14.29

2.54 ± 2.12

1.95 (0–9.25)

1.37 ± 0.99

≥60

0.49 ± 0.17

0.43 (0.26–2.98)

0.49 (0.31–2.20)

0.68 (0.22–2.48)

1.59 (0.21–5.37)

6.24 (0.29–17.81)

19.94 ± 64.44

2.86 ± 2.56

1.72 (0.13–11.01)

1.28 ± 0.84

P value

0.92

0.69

0.92

0.74

0.63

0.33

0.45

0.6

0.32

0.72

Gender

          

Male

0.54 ± 0.16

0.51 (0.31–2.98)

0.55 (0.22–2.2)

0.68 (0.22–2.48)

1.42 (0.02–7.79)

5.61 (0.07–13.41)

6.79 ± 7.35

2.54 ± 2.19

1.89 (0.13–9.25)

1.15 ± 0.55

Female

0.45 ± 0.21

0.42 (0.11–1.63)

0.45 (0.2–1.25)

0.55 (0.01–1.45)

1.59 (0.25–7.18)

6.51 (0.69–39.44)

19.82 ± 56.45

2.78 ± 2.41

1.73 (0–11.01)

1.47 ± 1.11

P value

0.06

0.028

0.08

0.58

0.35

0.07

0.19

0.69

0.41

0.15

Anatomical site

          

GBC

0.47 ± 0.20

0.42 (0.11–2.98)

0.46 (0.2–2.2)

0.65 (0.01–2.48)

1.56 (0.02–7.79)

6.33 (0.07–39.44)

16.03 ± 47.12

2.74 ± 2.16

1.72 (0–11.01)

1.34 ± 0.98

Tongue

0.60 ± 0.14

0.52 (0.35–0.76)

0.59 (0.47–0.92)

0.66 (0.42–1.32)

1.63 (0.54–2.44)

4.36 (0.48–9.37)

5.28 ± 5.06

2.31 ± 3.05

2.69 (0.36–4.3)

1.28 ± 0.61

P value

0.05

0.16

0.01

0.85

0.99

0.09

0.12

0.59

0.25

0.84

Clinical stage

          

I or II

0.60 ± 0.20

0.55 (0.34–0.82)

0.67 (0.43–0.78)

0.77 (0.4–1.11)

0.84 (0.58–1.61)

2.17 (0.48–9.37)

2.80 ± 2.39

1.17 ± 0.63

3.14 (1.73–6.14)

0.92 ± 0.26

III or IV

0.49 ± 0.20

0.44 (0.23–2.98)

0.51 (0.22–2.2)

0.6 (0.01–2.48)

1.61 (0.02–7.79)

5.94 (0.07–39.44)

17.11 ± 48.91

2.84 ± 2.49

1.82 (0.26–9.25)

1.40 ± 1.01

P value

0.33

0.63

0.39

0.68

0.06

0.1

0.05

0.004

0.17

0.03

Tumour Size

          

T1 or T2

0.56 ± 0.16

0.44 (0.34–0.82)

0.58 (0.42–0.78)

0.79 (0.4–1.13)

1.01 (0.54–1.70)

2.93 (0.48–15.76)

3.56 ± 3.52

0.95 ± 0.62

2.73 (0.53–7.9)

1.02 ± 0.28

T3 or T4

0.49 ± 0.21

0.46 (0.23–2.98)

0.49 (0.22–2.2)

0.55 (0.01–2.48)

1.67 (0.02–7.79)

5.94 (0.07–39.44)

19.02 ± 52.15

3.14 ± 2.53

1.75 (0.26–9.25)

1.44 ± 1.07

P value

0.31

0.91

0.23

0.13

0.006

0.21

0.07

≤ 0.0001

0.11

0.03

Nodal invasion

          

N-

0.60 ± 0.18

0.55 (0.34–0.82)

0.67 (0.43–0.98)

0.64 (0.4–1.11)

0.84 (0.45–1.61)

1.84 (0.48–9.37)

2.20 ± 2.09

1.48 ± 0.85

4.24 (1.73–9.25)

0.85 ± 0.23

N+

0.49 ± 0.20

0.44 (0.23–2–98)

0.51 (0.22–2.2)

0.6 (0.01–2.48)

1.65 (0.02–7.79)

6.15 (0.07–39.44)

17.82 ± 49.88

2.87 ± 2.54

1.75 (0.26–7.9)

1.43 ± 1.02

P value

0.22

0.63

0.31

0.78

0.009

0.007

0.04

0.01

0.01

0.003

Histological grade

          

G1/well

0.53 ± 0.25

0.43 (0.23–1.63)

0.46 (0.22–1.25)

0.67 (0.22–1.45)

1.59 (0.02–7.79)

7.52 (0.07–39.44)

21.97 ± 68.38

3.42 ± 2.95

2.21 (0.26–11.01)

1.43 ± 0.88

G2/moderate

0.47 ± 0.13

0.44 (0.26–0.85)

0.52 (0.34–0.98)

0.57 (0.01–1.13)

1.60 (0.45–7.18)

5.28 (0.67–15.76)

9.79 ± 14.40

1.99 ± 1.33

1.74 (0.28–9.25)

1.18 ± 0.97

P value

0.34

0.78

0.96

0.23

0.77

0.25

0.41

0.04

0.42

0.33

Smoking

          

Yes

0.56 ± 18

0.46 (0.32–2.98)

0.55 (0.22–2.2)

0.68 (0.22–2.48)

1.23 (0.02–4.92)

3.6 (0.07–13.41)

4.72 ± 4.76

2.62 ± 2.54

1.96 (0.27–9.25)

1.06 ± 0.59

No

0.48 ± 0.20

0.44 (0.23–1.63)

0.47 (0.27–1.25)

0.59 (0.01–1.45)

1.64 (0.25–7.79)

6.27 (0.69–39.44)

18.90 ± 52.86

2.73 ± 2.38

1.84 (0.26–7.90)

1.43 ± 1.05

P value

0.21

0.43

0.12

0.62

0.07

0.03

0.1

0.88

0.72

0.11

Tobacco chewing

          

Yes

0.47 ± 0.17

0.44 (0.23–2.98)

0.46 (0.27–2.2)

0.65 (0.01–2.48)

1.61 (0.25–7.18)

5.94 (0.69–17.81)

19.41 ± 54.98

2.89 ± 2.65

1.72 (0.26–7.9)

1.46 ± 1.07

No

0.55 ± 0.25

0.43 (0.26–1.25)

0.55 (0.22–1.25)

0.66 (0.22–1.45)

1.25 (0.02–7.79)

4.32 (0.07–39.44)

6.10 ± 5.51

2.31 ± 1.76

3.44 (0.36–9.25)

1.04 ± 0.62

P value

0.22

0.74

0.24

0.66

0.27

0.13

0.15

0.42

0.06

0.07

Alcohol intake

          

Yes

0.52 ± 0.16

0.57 (0.32–2.98)

0.53 (0.22–2.2)

0.66 (0.22–2.48)

1.65 (0.02–4.92)

5.46 (0.07–13.41)

7.15 ± 7.41

2.97 ± 2.59

1.75 (0.27–5.97)

1.17 ± 0.61

No

0.49 ± 0.21

0.42 (0.23–1.63)

0.47 (0.27–1.25)

0.65 (0.01–1.45)

1.56 (0.25–7.79)

6.38 (0.48–39.44)

18.32 ± 53.62

2.60 ± 2.35

2.09 (0.26–9.25)

1.39 ± 1.07

P value

0.55

0.06

0.38

0.92

0.94

0.3

0.21

0.62

0.54

0.34

  1. For miRNAs that followed Gaussian distribution, the expression levels are provided as mean ± SD. For miRNAs that did not follow Gaussian distribution, the expression levels are provided as median (range). The P-Value for significance was adjusted for multiple hypothesis testing to P = 0.05/10 = 0.005. Thus a P-value between 0.05 and 0.005 should be regarded as borderline significance. GBC, gingivo-buccal complex
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Molecular Cancer

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