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Table 1 Relationship between clinicopathological features and serum levels of TIMP-1 in breast cancer patients

From: Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer

   

TIMP-1 level (ng/ml)

p value

  

N

Mean

SD

Rang

All study subjects

81

211.2317

82.4088

40.1078–414.3112

 

Diagnostic category

    

<0.001

 

Benign

22

159.8383

58.3779

40.1078–239.5306

 
 

Malignant

59

230.3953

82.2059

73.2381–414.3112

 

Age

    

0.985

 

<50

22

230.1297

79.5451

78.9473–378.5845

 
 

≧50

37

230.5533

84.8323

73.2381–414.3113

 

T status

    

0.386

 

≦2

24

215.8122

86.4862

73.2381–414.3113

 
 

>2

23

238.4916

90.9452

86.1807–404.1802

 

Lymph node

    

0.798

 

0

30

221.8737

89.6307

73.2381–414.3113

 
 

≧1

19

228.2739

76.2754

86.1807–324.1554

 

ER

    

0.002

 

Negative

24

268.9795

82.9122

73.2381–324.1554

 
 

Positive

35

203.9396

71.4596

86.1807–414.3113

 

PR

    

0.030

 

Negative

34

250.1643

83.3048

73.2381–324.1554

 
 

Positive

25

203.5096

74.0452

75.7956–414.3113

 

HER2+

    

0.120

 

Negative

38

242.7811

70.3116

86.1807–404.1802

 
 

Positive

21

207.971

98.1427

73.2381–414.3113

 

Ki-67(%)

    

0.597

 

<15 %

20

238.4001

62.2747

142.3562–378.5845

 
 

≧15 %

39

226.2903

91.2385

73.2381–414.3113

 

Molecular subtype

     
 

Luminal-A

25

230.8728

58.3779

134.5391–324.1554

<0.001

 

Luminal-B

10

136.6069

61.2456

73.2381–250.8275

0.327

 

HER2+

11

272.8475

78.5198

126.9324–414.3113

<0.001

 

TNBC

13

280.6168

74.7404

143.2887–404.1802

<0.001

  1. Serum was collected from 81 patients before surgery, including 22 benign and 59 malignant. Serum TIMP-1 level was detected by ELISA. Before detection, the serum samples were diluted 1:50 with 1 % BSA. ELISA was done according to the manufacturer’s instructions. Student’s T test was used to assess whether the mean of different group has statistically difference
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Molecular Cancer

ISSN: 1476-4598