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Fig. 7 | Molecular Cancer

Fig. 7

From: ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells

Fig. 7

RhoA inhibition decreases both the proliferative activity and motility of the cancer cells. a RhoA expression levels in Hs766T cells treated with negative control siRNA (siNC) or siRNAs for RhoA were assayed by Western blotting. b and c Cell growth in Hs766T cells after knockdown of RhoA and treatment with the RhoA-specific inihibitor, CCG-1423, was examined at 72 h by a colorimetric modified MTT assay (n = 4). Statistical analysis was conducted by Student’s t-test as shown (**p <0.01). d Cell migration and invasiveness assays of Hs766T cells with gene silencing of RhoA and treated with 2.8 μM of CCG-1423 (n = 4) were conducted using a transwell chamber. The scale bars represent 500 μm

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Molecular Cancer

ISSN: 1476-4598