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Fig. 2 | Molecular Cancer

Fig. 2

From: Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

Fig. 2

Drug sensitivity driven clustering is not linked to transcriptomics subtyping of TNBC cell lines. a Table representing the classification of TNBC cell lines according to gene expression profile according to Lehmann et al. [4]. The cell lines are assigned with different colors to represent different subtypes. b Heat map based on selective DSS (toxicity, as compared to a control set of 30 cell lines) with compound clustering shown vertically and cell line clustering horizontally. Only a portion of the compound set is shown. See Additional file 5: Figure S1 for full heat map. The cell line clustering based on drug vulnerabilities fails to resemble transcriptomics-based classifications (subtypes color coded as per table on the left)

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Molecular Cancer

ISSN: 1476-4598