Fig. 4

Activation of Pyk2 in advanced serous ovarian cancer. A tissue microarray containing sections of 120 tumors from women with advanced serous ovarian cancer was stained with antibodies specific for pPyk2 and pFAK. Tumors were scored as negative, weakly positive (1+), moderately positive (2+) or intensively positive (3+). a Representative images of immunoperoxidase-stained tissue for pFAK and pPyk2 demonstrating either negative staining (0), weak (1+), moderate (2+) and intensive staining (3+). None of the tumors stained negative for pFAK. b Kaplan-Meier curves for progression-free and overall survival. The graphs show women who had advanced serous ovarian carcinoma with pPyk2 positive tissue staining and women who had advanced serous ovarian carcinoma with no pPyk2 expression