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Fig. 9 | Molecular Cancer

Fig. 9

From: Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis

Fig. 9

Proposed mechanism for ITSN-1s-mediated Eps8/Cbl/Sos1 interaction and Rac1-dependent LC cell migration and metastasis. ITSN-1s enhances Cbl-Eps8 interaction leading to ubiquitination and degradation of Eps8. The preferential formation of Cbl-Eps8 leads to impaired assembly of Sos1-Eps8, leading to deactivation of Rac1. Rac1 deactivation reorganizes the cytoskeleton structure to increase thick actin bundles, increase focal adhesion complexes and collapse of the vimentin filament network altogether leading to decreased LC cell migration and metastasis

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Molecular Cancer

ISSN: 1476-4598