Table 2 Characterization of Treg/Th17 ratios in malignant pleural effusions
From: Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
Pleural effusion type compared | Observed characteristics of malignant pleural effusion (Relative to pleural effusion type compared) | References |
|---|---|---|
Parapneumonic | ↑ Treg (CD4+CD25+FoxP3+)/Th17(CD4+IL-17+) ratio ↑ Foxp3/RORγt ratio | [139] |
Malignant (with low Treg/Th17 ratio) | ↓ Overall survival with high Treg/Th17 in malignant pleural effusions | |
Non-chronic diseases | ↓Treg (CD4+CD25+CD127low/−)/Th17 (CD3+CD4+RORγt+) ratio a ↑ IL-17A+CD4+ cells ↓ CCR6+ Th17 cells | [138] |
Tuberculous | No significant difference in Treg (CD4+CD25+CD127low/−)/Th17 (CD3+CD4+RORγt+) ratio ↑ IL-17A+CD4+ cells ↓ CCR6+ Th17 cells |