Table 1 PI3 kinase regulated transcription factors that can impact the expression of ARRB1 genetic locus
S.No | Gene | Log2 FC p-Akt high vs low | No of binding sites | Regulation in GBM Log2 fold change | Correlation with ARRB1 (R) | p-value |
|---|---|---|---|---|---|---|
1 | ZIC3 | −0.53 | 6 | −0.35 (Down) | +0.085 | 0.0408 |
3 | SOX6 | 0.50 | 4 | 0.57 (Up) | −0.125 | 0.0025 |
4 | INSM1 | 0.50 | 2 | 0.69 (Up) | −0.141 | 0.0006 |
5 | ZNF300 | 0.41 | 1 | 1.69 (Up) | −0.230 | <0.0001 |