Fig. 4
From: Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
Sodium bicarbonate potentiates the anticancer efficacy of rapamycin. a HT29 xenograft growth curves treated with vehicle, sodium bicarbonate (200 mmol/L drinking water), rapamycin (3 mg/kg i.p. per day) or a combination of both. b HT29 xenograft growth curve treated with sodium bicarbonate (200 mmol/L drinking water) and rapamycin (3 mg/kg i.p. per day). c MC-38 allograft growth curves treated as under a. Arrows denote the start of treatment with rapamycin and vehicle at a mean graft volume of 25 mm3. **** p < 0.0001, *** p < 0.001, n = 5/group, Two-way ANOVA