Fig. 5From: Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitorsBicarbonate induces mTORC1 activity, increases necrosis and apoptosis and potentiates rapamycin efficacy. Serial sections of HT29 tumor xenografts and MC-38 tumor allografts were stained with H & E and with phospho S6, cleaved caspase 3 and PCNA antibodies. Representative images of immunohistochemistry are shown. Scale bar, 100 μmBack to article page