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Fig. 6 | Molecular Cancer

Fig. 6

From: Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

Fig. 6

Effect of AhR inhibition on CSC apoptosis. a and b MCF-7 cells were treated for 72 h with DOX 400 or 800 ng/ml in the presence and absence of α-NF (10 μM) (a) or AhR shRNA (b). c and d SP and non-SP MCF-7 cells were treated for 72 h with DOX 400 ng/ml in the presence and absence of α-NF (10 μM). The cells were collected and then stained with annexin V–APC/DAPI. The percentage of cells underwent to apoptosis was then analysed on LSRII Flow Cytometer. One of the three representative experiments using different cell preparations was only shown. The values represent mean ± SEM (n = 3). *; p < 0.05 compared to control. #; p < 0.05 compared to DOX treatment

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Molecular Cancer

ISSN: 1476-4598