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Fig. 5 | Molecular Cancer

Fig. 5

From: miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

Fig. 5

miR-4775 induces EMT in CRC. a The cell phenotype is significantly altered after transfection of miR-4775 mimics or anti-miR-4775 mimics into SW480 or SW620, respectively, compared with their control groups (magnification × 200). b Fold changes in EMT marker mRNAs upon miR-4775 overexpression or downregulation compared with their control groups (**p < 0.01, ***p < 0.001). c Western blotting analyses of EMT markers in cells overexpressing or knocked down for miR-4775 and control cells. d Immunofluorescence staining analysis of EMT markers in cells overexpressing or knocked down for miR-4775 and control cells. e IHC staining analysis of EMT markers in cells overexpressing or knocked down for miR-4775 and their control subcutaneous xenograft tumors in nude mice (magnification × 200)

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