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Fig. 3 | Molecular Cancer

Fig. 3

From: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

Fig. 3

miR-939 inhibits gastric cancer metastasis in vitro and in vivo. a the wound healing rate in miR-939-transfected cells was significantly inhibited, while accelerated in miR-939-silenced cells. b the number of migrated cell was decreased in miR-939-overexpressing, while increased in miR-939-silenced GC cells, as assessed by transwell migration assay. c the number of invaded cell was decreased in miR-939-overexpressing, while increased in miR-939-silenced GC cells, as assessed by Matrigel invasion assay. d miR-939 inhibits tumor metastasis in vivo. Left panel: hematoxylin and eosin (H&E) staining was performed on serial sections of metastatic tumors (M) and normal (N) lung. Arrows: lesions of lung. The Ki-67 IHC staining was performed on tumor metastases. Right panel: the number of nodules was qualified on lungs of SCID mice (n = 6 per group) 4 weeks after tail vein injection of SGC-7901-scramble (left bars) and SGC7901-miR-939 cells (right bars)

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