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Table 2 Univariate and multivariate analysis of factors associated with overall survival and time to recurrence in GC patients

From: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

  Overall Survival Time To Recurrence
Clinical Variables HR (95% CI) P value HR (95% CI) P value
Univariate analysis
 miR-939 (high versus low) 0.122 (0.053–0.281) <0.001 0.228 (0.121–0.429) <0.001
 SLC34A2 (high versus low) 4.555 (2.241–9.260) <0.001 4.179 (2.247–7.769) <0.001
 Gender (female versus male) 0.559 (0.294–1.060) 0.075 0.791 (0.441–1.420) 0.433
 Age (≥60 versus < 60 years) 1.188 (0.614–2.297) 0.609 1.063 (0.588–1.921) 0.839
 T status (T4 versus T1 + 2 + 3) 2.242 (1.182–4.254) 0.013 1.837 (1.042–3.239) 0.035
 N status (N2 + 3 versus N1 + 2) 6.324 (2.463–16.239) <0.001 4.928 (2.301–10.555) <0.001
 Clinical stage (III versus II) 14.407 (3.461–59.972) <0.001 9.070 (3.250–25.313) <0.001
 Tumor size (≥5 cm versus < 5 cm) 2.080 (1.097–3.947) 0.025 2.057 (1.164–3.631) 0.013
 Tumor grade (G3 versus G1 + 2) 1.371 (0.667–2.828) 0.389 1.354 (0.716–2.560) 0.351
Combination of miR-939 and SLC34A2
 II versus I 3.482 (0.778–15.581) 0.103 2.776 (0.971–7.939) 0.057
 III versus I 6.822 (1.801–25.842) 0.005 2.971 (1.074–8.219) 0.036
 IV versus I 24.212 (7.049–83.161) <0.001 11.118 (4.688–26.368) <0.001
Multivariate analysisa
 miR-939 (high versus low) 0.167 (0.070–0.398) <0.001 0.328 (0.168–0.640) 0.001
 SLC34A2 (high versus low) 2.287 (1.050–4.981) 0.037 2.517 (1.276–4.965) 0.008
 T status (T4 versus T1 + 2 + 3) 1.642 (0.833–3.233) 0.152 1.403 (0.776–2.533) 0.262
 N status (N2 + 3 versus N1 + 2) 3.812 (1.426–10.188) 0.008 3.143 (1.418–6.966) 0.005
 Tumor size (≥5 cm versus < 5 cm) 1.784 (0.929–3.425) 0.082 1.754 (0.982–3.133) 0.058
Multivariate analysisb
Combination of miR-939 and SLC34A2
 II versus I 3.320 (0.734–15.015) 0.119 2.865 (0.980–8.376) 0.055
 III versus I 7.988 (2.077–30.727) 0.003 3.444 (1.224–9.689) 0.019
 IV versus I 15.959 (4.498–56.619) <0.001 7.970 (3.249-19.546) <0.001
T status (T4 versus T1 + 2 + 3) 1.697 (0.852–3.382) 0.133 1.423 (0.782–2.590) 0.249
N status (N2 + 3 versus N1 + 2) 3.862 (1.443–10.339) 0.007 3.157 (1.424–7.001) 0.005
Tumor size (≥5 cm versus < 5 cm) 1.833 (0.949–3.543) 0.071 1.789 (0.998–3.240) 0.055
  1. Combination of miR-939 and SLC34A2: I, High miR-939 and Low SLC34A2; II High miR-939 and High SLC34A2; III Low miR-939 and Low SLC34A2; IV Low miR-939 and High SLC34A2
  2. Analysis was conducted using univariate or multivariate Cox proportional hazards regression
  3. aMultivariate analysis of miR-939, SLC34A2, T status, N status and Tumor size
  4. bMultivariate analysis of the combination of miR-939 and SLC34A2, T status, N status and Tumor size