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Table 2 Colon TIC marker combinations

From: Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

  assessment of self-renewal cellular system
Marker combinations References In vitro In vivo cell lines patients mouse
CD166+/CD44+ [Dalerba et al., 2007] 1   1   1  
EpCAMhigh/CD44+ [Dalerba et al., 2007] 1
[Kai et al., 2009] 2
2 1
2
2 1  
CD24high/CD29+ [Ghazvini et al., 2013] 1   1    1
CD133+/CD44+ [Haraguchi et al., 2008] 1
[Chen et al., 2011] 2
1 1
2
1
2
1  
CD133+/CD49f+ [Haraguchi et al., 2013] 1   1   1  
CD44+/CD49f+
CD24+/CD44+ [Yeung et al., 2010] 1 1 1 1   
CD44+/CD133 [Wang et al., 2012] 1 1   1   
CD133+/CD24+ [Vermeulen et al., 2008] 1 1    1  
CD133+/CD24- [Vermeulen et al., 2008] 1
[Haraguchi et al., 2008] 2
1
2
2 2 1
2
 
CD133+/CD44-
CD133+/CD44+
CD133+/CD166-
CD133+/CD166+
CD166+/CD44+ [Muraro et al., 2012] 1 1 1 1   
CD24+/CD44+
CD44+/CD166+/EpCAMlow [Collura et al., 2013] 1 1  1   
CD44+/CD166+/EpCAMhigh
CD133+/CD26+/CD44+
CD133+/CD26+/CD44-
[Pang et al., 2010] 1 1 1   1  
CD133+/CD26-/CD44+
CD133+/CD26-/CD44-
CD133-/CD26+/CD44+
CD133-/CD26+/CD44-
CD133-/CD26-/CD44+
CD133-/CD26-/CD44- 1 1  1  
  1. : correlation between self-renewal and expression of surface markers
  2. −: no correlation between self-renewal and expression of surface markers