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Table 3 Signaling pathways implicated in TIC regulation

From: Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

Signaling Pathways Property References
Wnt/β-catenin Self-renewal [111, 126, 127, 152155]
BMI-1 Self-renewal, stemness [135, 156158]
ID1/ID3 Self-renewal [96, 159]
Hedgehog Self-renewal, stemness [127, 134, 160162]
Notch Self-renewal [127, 131, 132, 163165]
JAK/STAT Self-renewal, stemness, tumorigenic potential [138140, 166171]
TGF-β EMT, stemness, dual role in CRC [10, 125, 172]