Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

Table 3 Signaling pathways implicated in TIC regulation

Signaling Pathways	Property	References
Wnt/β-catenin	Self-renewal	[111, 126, 127, 152–155]
BMI-1	Self-renewal, stemness	[135, 156–158]
ID1/ID3	Self-renewal	[96, 159]
Hedgehog	Self-renewal, stemness	[127, 134, 160–162]
Notch	Self-renewal	[127, 131, 132, 163–165]
JAK/STAT	Self-renewal, stemness, tumorigenic potential	[138–140, 166–171]
TGF-β	EMT, stemness, dual role in CRC	[10, 125, 172]

ISSN: 1476-4598