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Fig. 2 | Molecular Cancer

Fig. 2

From: Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin

Fig. 2

Effect of CDDP and TSPC on melanoma cell lines. a Log-dose response curves for SK-MEL-5 and SK-MEL-28 cells following treatment with CDDP or TSPC at 72 h. b Distribution of cells between cell cycle phases after CDDP and TSPC exposure. (*, p < 0.05). c Apoptotic effect of CDDP and TSPC evaluated by APO-BrDUTunel assay. The experiments were carried out in triplicate. The results are shown as the mean ± standard deviation. d Effect of CDDP and TSPC in cell cycle regulatory proteins TP53, CDKN1A, CDKN1B, CDKN2B, CDK2, CDK4, CCND1 (cyclin D1), CCNE2 (cyclin E2), and P-CDK1 as determined by Western blot analysis. GAPDH is shown as loading control

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