Fig. 7From: Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-PlatinTSPC induces cell cycle G1 arrest probably mediated by CDKN1A and CDKN1B CKIs in a TP53-independent manner, while CDDP induces S and G2/M arrest via TP53/CDKN1A pathway in SK-MEL-5, and preventing dephosphorylation of CDK1 in both cell linesBack to article page