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Fig. 6 | Molecular Cancer

Fig. 6

From: SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

Fig. 6

Increased levels of TUSC3 suppress the proliferation and migration of breast cancer cells. a Establishment of cell line (ZR7530) overexpressing TUSC3. b TUSC3 overexpression leads to reduced proliferation of ZR7530 cells. Data are represented as mean ± SD (n = 3 for each group, p < 0.01). c TUSC3 overexpression suppresses colony formation efficiency and reduces the size of individual clones in agar assay. Data are represented as mean ± SD (n = 3 for each group, p < 0.01). d Migration of cancer cells are inhibited by TUSC3 overexpression as revealed by wound healing assay (p < 0.01). e Overexpression of TUSC3 reduces the invasion capability of ZR7530 cells in the transwell assay (p < 0.01). The cell number present at the lower side of the membrane of the insert is counted and presented in the graph. * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001 vs control, and the error bars indicate the mean ± standard deviation (SD)

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Molecular Cancer

ISSN: 1476-4598