Fig. 1
From: Emerging roles of lipid metabolism in cancer metastasis
Schematic representation of lipid metabolism implicated in cancer metastasis. Cancer cells fine-tune the anabolic/catabolic balance to meet the increasing metabolic requirements and lead to aggressive progression. In addition, lipid raft within cell membrane provides the platform to mediate lipid signaling contributing to metastasis. During the progress of metastasis, cancer cells can couple lipid metabolism with supporting host cells in the microenvironment to benefit their distant metastasis. ACLY, ATP citrate lyase; ACC,acetyl-CoA carboxylase; ACS,acyl-CoA synthetases; CPT1, carnitine palmitoyl transferase 1; DAG, diacylglycerol; DGAT, diacylglycerol acyltransferase; ER, endoplasmic reticulum; ETC, electron transport chain; FA, fatty acid; FAO, fatty acid oxidation; FASN, fatty-acid synthase; GPL, glycerophospholipid; Lyso-PL, lysophospholipid; MAG, monoacylglycerol; MAGL, monoacylglycerol lipase; NADH, nicotinamide adenine dinucleotide; NADPH, nicotinamide adenine dinucleotide phosphate; PA, phosphatidic acid; PAP, phosphatidic acid phosphatase; PC, phosphatidylcholine; PLA2,Phospholipase A2; PLD, Phospholipase D; ROS, reactive oxygen species; SCD, stearoyl-CoA desaturases; TG, triacylglycerol