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Fig. 1 | Molecular Cancer

Fig. 1

From: IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

Fig. 1

IGF2BP3 is up-regulated in GC. a Top ten most up-regulated genes from gene expression microarray analysis in nine GC cell lines. IGF2BP3 ranked the top one among the list. b The mRNA and protein expression of IGF2BP3 in 12 GC cell lines compared with immortalized gastric epithelium cell line GES-1. c IGF2BP3 was highly expressed in 311 GC samples compared with normal gastric tissues (from http://medical-genome.kribb.re.kr/GENT/, P < 0.001). d Increased expression of IGF2BP3 in primary gastric tumors compared with adjacent non-tumorous tissues (NCBI/GEO/GSE63089, P < 0.001). e mRNA expression of IGF2BP3 in intestinal and diffuse type GC (Lauren classification) (TCGA cohort, n = 193; **, P < 0.001) f IGF2BP3 mRNA expression in four molecular subtypes of GC (TCGA cohort, n = 313; **, P < 0.001). g Proportion of genetic alterations of IGF2BP3 (from http://www.cbioportal.org/; n = 258)

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Molecular Cancer

ISSN: 1476-4598