Fig. 1
From: Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer
Skp2 is regulated by the mTORC1 in gastric cancer cells. a The expression of Skp2 was associated with phosphorylate mTOR in different gastric cancer cell lines. (b, c) mTORC1 pathway prevented by rapamycin (b) and siRNA (c) in BGC 823 cells downregulated the expression of Skp2. (d, e) The enhancement of mTOR activity by overexpression mTOR (d) or IGF-1 (e) in BGC 823 cells leads to upregulation of Skp2 expression. The 293Â T cell were treated IGF-1 at various time points after starvation 12Â h