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Fig. 4 | Molecular Cancer

Fig. 4

From: Cripto-1 acts as a functional marker of cancer stem-like cells and predicts prognosis of the patients in esophageal squamous cell carcinoma

Fig. 4

Correlation of CR-1 expression with clinical pathological parameters and overall survival rates in ESCC patients. A (a) Representative immunohistochemical images showed few CR-1high cells that were localized in the basal layer of normal squamous epithelium. (b) High level of CR-1 protein abundance in ESCC tissues. (c, d) CR-1 highly expressed in both primary tumor and the corresponding metastatic lymph node. B The IHC score of CR-1 in cancerous tissues was higher than that of adjacent normal tissues. C Quantitative analysis of CR-1 mRNA in 11 fresh surgical tumor specimens and the adjacent normal tissues showed that CR-1is highly expressed in cancerous tissues. D CR-1 expression was significantly associated with TNM stage, depth of invasion, and lymph node metastasis. E Kaplan-Meier estimation of correlation between overall survival and CR-1 expression in ESCC patients indicated that the patients with CR-1high had shorter overall survival time than those with CR-1low. F Survival analysis of ESCC patients from TCGA dataset indicated that patients with CR-1high suffered poorer overall survival

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Molecular Cancer

ISSN: 1476-4598