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Fig. 6 | Molecular Cancer

Fig. 6

From: Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis

Fig. 6

Differential TEX19-assocaited control of TE and piRNA regulatory genes in distinct human cancer cell lines: a RT-qPCR analysis of HERV genes in SW480 cells depleted for TEX19 mRNA indicates that TEX19 regulates HERV gene expression. b RT-qPCR analysis of expression of piRNA regulator genes (PIWIL1-4) in three cancer cell lines (A2780, H460, SW480) depleted for TEX19 mRNA indicates that whilst TEX19 controls some, but not all piRNA genes (PIWIL1-3) in SW480, this is not a universal feature of TEX19 in all cancer cell lines. c RT-qPCR analysis of HERV genes in SW480 cancer cells depleted for PIWIL1 mRNA indicates that PIWIL1 regulates HERV gene expression. d RT-qPCR analysis of SW480 cancer cells depleted for both TEX19 and PIWIL1 mRNA demonstrates that TEX19 regulates HERV gene expression in SW480 cells via a PIWIL1-dependent pathway. e RT-qPCR analysis of mRNA extracts from a range of cancer lines indicates that unlike TEX19, expression of PIWIL1 is not universal in these cancer cell lines indicating that a functional link between TEX19 and PIWIL1 is not universal. f RT-qPCR analysis of HERV gag gene in seven cancer cell lines depleted for TEX19 mRNA (+/- siRNA = +/- TEX19 siRNA). g RT-qPCR analysis of HERV rec gene in seven cancer cell lines depleted for TEX19 mRNA (+/- siRNA = +/- TEX19 siRNA)

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