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Table 2 Univariate and multivariate Cox regression analyses of the 2-lncRNA signature

From: Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma

Characteristics

Univariate analysis

Multivariate analysis

HRa(95% CI)

P-value

HR(95% CI)

P-value

Training dataset

 2-lncRNA signature

2.59(1.60,4.18)

1.00e–04

2.43(1.49,3.94)

3.45e–04

 Age ≥ 60 vs <60 years

1.41(0.85,2.35)

0.18

1.33(0.79,2.21)

0.28

 Gender female vs male

1.09(0.66,1.81)

0.74

1.10(0.66,1.84)

0.72

 Stage I vs II

2.80(1.27,6.16)

0.011

2.12(0.95,4.74)

0.066

GSE50081

 2-lncRNA signature

1.91(1.11,3.29)

0.020

1.82(1.03,3.22)

0.039

 Age ≥ 60 vs <60 years

1.50(0.64,3.51)

0.35

1.62(0.68,3.87)

0.27

 Gender female vs male

0.74(0.43,1.28)

0.29

0.69(0.39,1.22)

0.20

 Smoking vs never-smoking

1.31(0.73,2.35)

0.36

1.07(0.58,1.97)

0.83

 Stage I vs II

2.54(1.45,4.44)

1.16e–03

2.49(1.40,4.41)

1.83e–03

GSE31210

 2-lncRNA signature

3.29(1.58,6.85)

1.45e–03

2.40(1.12,5.11)

0.024

 Age ≥ 60 vs <60 years

1.47(0.70,3.10)

0.31

1.59(0.76,3.37)

0.22

 Gender female vs male

0.59(0.29,1.22)

0.16

0.97(0.36,2.61)

0.95

 Smoking vs never-smoking

1.91(0.92,3.97)

0.084

1.60(0.59,4.33)

0.35

 Stage I vs II

4.30(2.09,8.83)

7.21e–05

3.42(1.62,7.26)

1.31e–03

  1. aHR, hazard ratio