Table 7 Fold-changes of expression of signatures in relation to ER (ER+/ER−) and their associated p-values between parentheses
From: In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer
Sub-cluster/signature | TCGA | GSE2034 | GSE3494 | METABRIC-disc | METABRIC-val |
|---|---|---|---|---|---|
C1a | 0.88 (0.006) | 0.94 (0.033) | 0.94 (7.5 × 10 −4 ) | 0.95 (1.1 × 10 −4 ) | 0.94 (1.5 × 10 −6 ) |
C1b | 0.77 (8.8 × 10 −18 ) | 0.89 (1.6 × 10 −11 ) | 0.91 (4.9 × 10 −16 ) | 0.91 (2.0 × 10 −29 ) | 0.90 (1.3 × 10 −38 ) |
C2a | 1.28 (8.3 × 10 −13 ) | 1.14 (2.1 × 10 −10 ) | 1.10 (1.9 × 10 −12 ) | 1.08 (1.3 × 10 −17 ) | 1.09 (4.1 × 10 −20 ) |
C2b | 0.56 (4.3 × 10 −28 ) | 0.74 (1.0 × 10 −23 ) | 0.86 (1.3 × 10 −14 ) | 0.79 (1.9 × 10 −59 ) | 0.81 (4.4 × 10 −51 ) |
C2c | 1.01 (0.78) | 1.01 (0.53) | 1.02 (0.16) | 1.02 (0.025) | 1.04 (5.4 × 10 −4 ) |
51-gene signature | 0.63 (1.4 × 10 −10 ) | 0.76 (1.8 × 10 −12 ) | 0.86 (7.0 × 10 −9 ) | 0.80 (2.0 × 10 −30 ) | 0.81 (1.7 × 10 −26 ) |
20-gene signature | 0.71 (0.003) | 0.81 (8.6 × 10 −4 ) | 0.96 (0.35) | 0.86 (3.4 × 10 −7 ) | 0.90 (2.6 × 10 −4 ) |