Skip to main content
Fig. 8 | Molecular Cancer

Fig. 8

From: MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

Fig. 8

PI3K/AKT signaling is essential for the biological function of miR-1296 in HCC. a HCCLM3 and Hep3B cells that were transfected with corresponding miRNA vectors were subjected to immunoblotting for phosphorylated AKT and AKT. b IGF-1 treatment promoted the migration and invasion of miR-1296 overexpressing HCCLM3 cells. c AKT inhibitor MK2206 treatment abrogated the effect of miR-1296 loss on mobility of Hep3B cells. d Western blot analysis indicated that modulating AKT phosphorylation reversed the effects of miR-1296 alteration on EMT process of HCC cells. *P < 0.05

Back to article page

Molecular Cancer

ISSN: 1476-4598