Fig. 1
From: 11q deletion in neuroblastoma: a review of biological and clinical implications
Molecular networks between genes involved in NB development by the data mining IPA software. Nine genes (red and green) on 11q recognized in regulatory networks involving MYCN, MAPK, PGE2, ATM and p53 (experimentally described interaction only). All genes presented in this figure are highly associated with cancer (27/36 molecules, p-value = 2.41E-18). Where appropriate, proteins (white) were added by IPA software to complete the pathway. Legend contains description of basic protein functions, nature of interaction and relation to commonly mutated genes in NB or 11q deletion [10, 134]