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Fig. 2 | Molecular Cancer

Fig. 2

From: Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Fig. 2

Hif-2α enhanced the activity of β-catenin. a Wnt-3a induced β-catenin promoted EMT while siRNA inhibited β-catenin blocked EMT in PANC-1 cells. b DFO promoted EMT, which was partially reversed by β-catenin interference by siRNA. c Hif-2α (A530T) promoted EMT, which was partially reversed by β-catenin interference by siRNA. d Hif-2α (A530T) transfection enhanced transcription activity of β-catenin in PANC-1 and SW 1990 cells regardless of oxygen availability. Knockdown of hif-2α reduced β-catenin activity as measured by luciferase reporter assays. *, P < 0.05; **, P < 0.01; ***, P < 0.001, as compared to pcDNA3, NaCl, or nc-siRNA. Representatives of three independent experiments

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Molecular Cancer

ISSN: 1476-4598