Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Table 2 Univariate and multivariate analyses indicated factors for patient survival

Variable	Univariate analysis		Multivariate analysis
Variable	HR	P value	HR (95% CI)	P value
Age (≥ 60/< 60)	1.057	0.833	-
Gender (male/female)	1.907	0.025	1.582 (0.882–2.839)	0.124
Disease stage (1/2)	0.568	0.033	0.661 (0.384–1.136)	0.134
Hif-2α (high/low)	2.214	0.028	2.693 (1.189–6.097)	0.018
Stroma (high/low)	1.221	0.585	-
TNM stage (I + II/III + IV)	0.638	0.207	-
Microvascular density (high/low)	0.977	0.937	-
Tumor location (head/body or tail)	0.851	0.463	-
Nerve invasion (yes/no)	1.239	0.411	-

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