Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

Table 1 Clinicopathologic parameters and circulating exosomal miR-222-3p level in 50 NSCLC patients

Parameters	NO. of Patients	Expression of miR-222-3p^a		P-value
Parameters	NO. of Patients	low	high	P-value
Overall	50	25	25
Age
≥ 60	24	14	10	0.396
< 60	26	11	15	0.396
Gender
Male	40	21	19	0.725
Female	10	4	6	0.725
Histology
Squamous	22	9	13	0.393
Adenocarcinoma	28	16	12	0.393
Differentiation
Well	3	1	2	0.820
Moderate	18	10	8
Poor	29	14	15
cTNM stage
II	6	4	2	0.489
III	22	12	10
IV	22	9	13
cT stage
cT1–2	27	16	11	0.256
cT3–4	23	9	14	0.256
cN stage
cN0	12	9	3	0.095
cN+	38	16	22	0.095
cM stage
cM0	28	20	8	0.001**
cM1	22	5	17	0.001**
Response after Gem^b
PR	27	19	8	0.006**
SD	7	3	4
PD	16	3	13

ISSN: 1476-4598