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Table 1 Clinicopathologic parameters and circulating exosomal miR-222-3p level in 50 NSCLC patients

From: Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

Parameters NO. of Patients Expression of miR-222-3pa P-value
low high
Overall 50 25 25  
Age
  ≥ 60 24 14 10 0.396
  < 60 26 11 15
Gender
 Male 40 21 19 0.725
 Female 10 4 6
Histology
 Squamous 22 9 13 0.393
 Adenocarcinoma 28 16 12
Differentiation
 Well 3 1 2 0.820
 Moderate 18 10 8
 Poor 29 14 15
cTNM stage
 II 6 4 2 0.489
 III 22 12 10
 IV 22 9 13
cT stage
 cT1–2 27 16 11 0.256
 cT3–4 23 9 14
cN stage
 cN0 12 9 3 0.095
 cN+ 38 16 22
cM stage
 cM0 28 20 8 0.001**
 cM1 22 5 17
Response after Gemb
 PR 27 19 8 0.006**
 SD 7 3 4
 PD 16 3 13
  1. aMedian miR-222-3p level is used as the cut-off
  2. b PD Progressive disease, SD Stable disease, PR Partial response
  3. P-value of Fisher’s exact test are shown. **P < 0.01
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