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Fig. 2 | Molecular Cancer

Fig. 2

From: MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells

Fig. 2

Prediction of MEG2 as a miR-181a-5p target. a Quantitative RT-PCR analysis of MEG2 mRNA expression levels in the same 20 pairs of GC and GN specimens. b Schematic description of the hypothetical duplex formed by the interaction between the MEG2 3′-UTR binding site (top) and miR-181a-5p (bottom). The calculated free energy value of the hybrid is indicated. The seed recognition sites are denoted in red. All nucleotides of the seed recognition sites are highly conserved in several species. c Quantitative RT-PCR analysis of miR-181a-5p expression levels in the same specimens. d Quantitative RT-PCR analysis of miR-181a-5p expression levels in the same gastric cell lines. e Pearson’s correlation scatter plot of the correlation between MEG2 protein and miR-181a-5p in GN specimens. f Pearson’s correlation scatter plot of the correlation between MEG2 protein and miR-181a-5p in GC specimens. g Pearson’s correlation scatter plot of the correlation between MEG2 protein and miR-181a-5p in 5 human GC cell lines and 1 human gastric epithelial cell line. *P < 0.05; **P < 0.01; ***P < 0.001

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