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Fig. 2 | Molecular Cancer

Fig. 2

From: Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

Fig. 2

CASC2 inhibited migration and invasion of HCC cells both in vitro and in vivo. a pcDNA/CASC2 could significantly increase CASC2 expression in MHCC-97H cells. b CASC2-siRNAs could significantly decrease CASC2 expression in Hep-3B cells. c Transwell assays showed that CASC2 restoration decreased migration and invasion abilities of MHCC-97H cells. d CASC2 knockdown facilitated migration and invasion of Hep-3B cells. e Representative pictures showed lung metastasis of HCC in mouse model (magnification: ×100). Black arrow showed the position of lung metastasis (left panels). Quantitative analysis was used to compare the lung metastasis nodules between these two groups (right panels). *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598