Fig. 6
![Fig. 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12943-017-0705-9/MediaObjects/12943_2017_705_Fig6_HTML.gif)
Overexpression of p300 reversed the cellular effects caused by NMI overexpression. a Cell viability was measured by MTT assay in A549 cells transfected with LacZ control plasmid, NMI overexpression plasmid, NMI + p300 overexpression plasmids, or NMI + HAT domain-deleted p300 overexpression plasmids. b COX-2 promoter activity was determined by luciferase reporter assay in A549 cells transfected with NMI and p300 overexpression plasmids. c PGE2 level was detected in the culture media of A549 cells transfected with NMI and p300 overexpression