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Fig. 4 | Molecular Cancer

Fig. 4

From: Role of the lncRNA ABHD11-AS1 in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC

Fig. 4

Effect of the lncRNA ABHD11 on in vivo tumor growth and metastasis ability as well as RhoC expression. The tumor xenograft volume in nude mice transfected with the lncRNA ABHD11-AS1 was greater than that in the mock nude mice (a, b and c). Tumor xenograft growth in the ABHD11-AS1-treated nude mice was faster than that in the control group (d). *P < 0.05. Macroscopic observation showed that the size and range of metastatic lesions were greater in the lncRNA ABHD11-AS1-transfected nude mice (f). Immunohistochemical analysis demonstrated a significant increase in RhoC expression in the ABHD11-AS1-transfected tumors compared with the control tumors both in the subcutaneously (e) and intraperitoneally injected nude mice (g). *P < 0.05

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Molecular Cancer

ISSN: 1476-4598