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Fig. 5 | Molecular Cancer

Fig. 5

From: Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer

Fig. 5

ZEB1-AS1 inhibited miR200c and promoted BMI1 expression. a, ZEB1-AS1 knockdown induced increased miR200c level and decreased BMI1 level. ZEB1-AS1 knockdown in DU145 and PC3 prostate cancer cells (ZEBAS1-KD1 and ZEBAS1-KD2) induced significant increase of miR200c and decreased BMI1 mRNA and protein levels. ZEB1 knockdown (ZEB1-KD1, ZEB1-KD2) produced similar effects. b, miR200c and BMI1 levels were rebuilded with ZEB1-AS1 re-expression in ZEB1-AS1 knockdown cells. Adenovirus-mediated ZEB1-AS1 re-expression in both ZEB1-AS1 knockdown and ZEB1 knockdown cells comparably induced significant decrease of miR200c level and increased BMI1 mRNA and protein levels. The plasmid pc-ZEB1 overexpressing ZEB1 (pcDNA3.1 as negative control) had the same effects

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Molecular Cancer

ISSN: 1476-4598