Fig. 3
From: Tumor-related interleukins: old validated targets for new anti-cancer drug development
the role of IL-1 in cell carcinogenesis and tumor metastasis. The interaction of IL-1 with its receptor activates the NFκB in different cell types. In cells involving in the malignancy transformation, it upregulates the gene of reactive oxygen species, nitrogen oxide intermediates and anti-apoptotic factors. In the inflammatory or endothelial cells it upregulates the genes expressing cytokines and factors supporting cells survival and invasion