Fig. 7
From: SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis
A model for SUMOylation of KHSRP inhibiting miRNA biogenesis. In brief, EGF or insulin can block the K87-SUMO1 modification on KHSRP through phosphorylation of KHSRP by PI3K/AKT pathway to promote its interaction with Drosha/DGCR8 and pri-miRNAs, sequentially affects a subset of miRNAs biogenesis. Reversely, KHSRP SUMO1 modification is enhanced in hypoxia condition, which leads to its cytoplasm shifting and alters the miRNA biogenesis profile to promote tumor processes. Thereby, K87-SUMO1 modification on KHSRP may play a critical function in tumorgenesis through regulating the microprocessor procedure of partial specific pri-miRNAs to generate mature miRNAs