Fig. 3
From: Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer
Linc-RoR KO abrogates ligand-independent activation of ER. a Linc-RoR KO suppresses estrogen deprivation-induced activation of ER. The intensity value is relative to GAPDH as 1. b Linc-RoR KO causes a significant reduction of ER non-genomic target genes mRNA level under E2-free condition. c Re-expression of linc-RoR restores activation of ER. d Linc-RoR is required for ER non-genomic target gene expression. Re-expression of linc-RoR confirms the capability of estrogen-independent activation, n = 3, *P < 0.05, **P < 0.01