Fig. 3From: A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patientsHOTTIP may regulate SCLC cell proliferation in vitro and xerograft tumor growth of in vivo. a Plate and soft agar colony formation assay was used to detect the effect of HOTTIP overexpression on SCLC cell proliferation in vitro. b Plate colony formation assay were used to detect the effect of HOTTIP knockdown on SCLC cell proliferation in vitro. c Images of nude mice with xerograft tumor in each group. d Excised tumors’ image from nude mice in each group. e Volume change curve of each group measured on the indicated days. f Tumor weights of each group were determined. *, P < 0.05; **, P < 0.01Back to article page