Table 1 Uni- and multivariate Cox regression analyses for OS including the four molecular classifications
From: Validation and comparison of the molecular classifications of pancreatic carcinomas
Characteristics | Univariate | Multivariate** w/ Moffitt tumor | Multivariate** w/ Moffitt stroma | Multivariate** w/ Collisson | Multivariate** w/ Bailey | Multivariate** w/ four classifications | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | HR [95CI] | P* | N | HR[95CI] | P* | N | HR[95CI] | P* | N | HR[95CI] | P* | N | HR[95CI] | P* | N | HR[95CI] | P* | ||
Age at diagnosis | >60 vs. ≤60 years | 364 | 1.21 [0.89–1.65] | 0.233 | |||||||||||||||
Sex | male vs. female | 367 | 1.13 [0.85–1.50] | 0.392 | |||||||||||||||
AJCC Stage | 2 vs. 1 | 515 | 2.36 [1.56–3.58] | 2.16E-04 | 215 | 1.52[0.24–9.63] | 0.658 | 209 | 0.56[0.1–3.32] | 0.527 | 215 | 0.64 [0.1–4.01] | 0.632 | 215 | 0.97 [0.14–6.62] | 0.979 | |||
3 vs. 1 | 3.54 [1.53–8.22] | 215 | 24.42[1.46–408] | 2.61E-02 | 209 | <NA>[NA-NA] | <NA> | 215 | 13.58[0.83–222.5] | 0.067 | 215 | 19.9[1.15–345.4] | 0.040 | ||||||
4 vs. 1 | 3.56 [1.53–8.30] | 215 | 0.00[0.00-Inf] | 0.999 | 209 | 0.00[0.00-Inf] | 0.999 | 215 | 0 [0-Inf] | 0.998 | 215 | 0 [0-Inf] | 0.999 | ||||||
Pathological type | other vs. ductal | 548 | 0.14 [0.03–0.55] | 5.27E-03 | 215 | 0.00[0.00-Inf] | 0.996 | 209 | 0.00[0.00-Inf] | 0.996 | 215 | 0 [0-Inf] | 0.996 | 215 | 0 [0-Inf] | 0.996 | |||
Pathological grade | 2 vs. 1 | 280 | 2.67 [1.15–6.21] | 3.14E-03 | 215 | 1.34[0.55–3.25] | 0.521 | 209 | 1.08[0.44–2.69] | 0.862 | 215 | 1.39 [0.57–3.38] | 0.470 | 215 | 1.31 [0.54–3.2] | 0.556 | |||
3 vs. 1 | 4.19 [1.79–9.81] | 215 | 1.71[0.7–4.18] | 0.242 | 209 | 1.29[0.53–3.18] | 0.574 | 215 | 1.55 [0.64–3.79] | 0.332 | 215 | 1.47 [0.6–3.58] | 0.400 | ||||||
4 vs. 1 | 4.78 [0.96–23.8] | 215 | 3.25[0.36–29.4] | 0.295 | 209 | 3.66[0.4–33.48] | 0.251 | 215 | 6.62 [0.61–71.8] | 0.120 | 215 | 3.27 [0.35–30.11] | 0.296 | ||||||
pT | 2 vs. 1 | 393 | 1.81 [0.75–4.36] | 1.85E-02 | 215 | 2.03[0.23–17.9] | 0.524 | 209 | 2.28[0.26–20.18] | 0.460 | 215 | 3.37 [0.37–30.38] | 0.280 | 215 | 1.75 [0.19–16.17] | 0.623 | |||
3 vs. 1 | 2.64 [1.16–5.98] | 215 | 2.74[0.19–38.8] | 0.456 | 209 | 4.61[0.33–63.47] | 0.254 | 215 | 5.66 [0.39–81.41] | 0.203 | 215 | 3.33 [0.22–51.1] | 0.389 | ||||||
4 vs. 1 | 3.90 [1.35–11.2] | 215 | <NA>[NA-NA] | <NA> | 209 | <NA>[NA-NA] | <NA> | 215 | <NA> [NA-NA] | <NA> | 215 | <NA> [NA-NA] | <NA> | ||||||
pN | 1 vs. 0 | 451 | 2.01 [1.5–2.7] | 2.86E-06 | 215 | 1.37[0.78–2.39] | 0.270 | 209 | 1.42[0.81–2.5] | 0.219 | 215 | 1.62 [0.93–2.84] | 0.090 | 215 | 1.4 [0.78–2.54] | 0.261 | |||
Moffitt “tumor” | classical vs. basal-like | 601 | 0.59 [0.48–0.73] | 1.17E-06 | 215 | 0.43[0.26–0.73] | 1.56E-03 | 574 | 0.91[0.67–1.24] | 0.557 | |||||||||
Moffitt “stroma” | normal vs. activated | 574 | 0.64 [0.51–0.8] | 8.46E-05 | 209 | 0.56[0.32–0.98] | 4.25E-02 | 574 | 0.73[0.57–0.92] | 9.07E-03 | |||||||||
Collisson | exocrine-like vs. classical | 601 | 0.90 [0.71–1.15] | 1.79E-03 | 215 | 0.74 [0.44–1.25] | 0.266 | 574 | 0.96[0.68–1.35] | 0.801 | |||||||||
quasi-mesenchymal vs. classical | 1.47 [1.13–1.91] | 215 | 0.75 [0.29–1.95] | 0.561 | 574 | 0.92[0.66–1.28] | 0.615 | ||||||||||||
Bailey | immunogenic vs. ADEX | 601 | 1.00 [0.70–1.42] | 1.03E-07 | 215 | 0.98 [0.43–2.24] | 0.961 | 574 | 0.93[0.59–1.47] | 0.759 | |||||||||
pancreatic progenitor vs. ADEX | 1.13 [0.82–1.57] | 215 | 1.64 [0.78–3.45] | 0.196 | 574 | 1.06[0.69–1.63] | 0.777 | ||||||||||||
squamous vs. *ADEX | 1.99 [1.50–2.65] | 215 | 2.3 [1.16–4.55] | 1.69E-02 | 574 | 1.69[1.09–2.62] | 1.94E-02 | ||||||||||||