Fig. 8
The restoration of miR-23b-3p reversed the drug resistance induced by MALAT1 overexpression in vivo. 1.0 × 107 SGC7901/VCR cells stably transfected with lenti-MALAT1 or lenti-NC or lenti-MALAT1+miR-23b-3p were subcutaneously injected into the flank of nude mice. Two weeks later, the mice were intraperitoneally injected with PBS containing CDDP (10 mg/kg) once per week. The mice were humanely killed on day 28, and the tumors were measured and photographed. Tumor volumes (a) and tumor growth curves (b) of subcutaneous implantation models of GC are shown. c Total protein fractions were isolated from cells derived from 3 representative xenograft samples from each group, and the LC3 proteins were detected by Western blot analysis. Data shown are means ± S.D. (n = 3; **, p < 0.01, two-tailed t-test). d A summary diagram presenting the interaction between MALAT1, miR-23b-3p, ATG12 and their effect on autophagy-associatated chemoresistance