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Fig. 1 | Molecular Cancer

Fig. 1

From: PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

Fig. 1

Overexpression of PKN2 is associated with better clinical outcome and high M1 content in human colon cancer. aThe protein expression of PKN2, CD68, CD206, CD86, CD163 and iNOS in a human colon cancer tissue array was detected by immunohistochemistry staining. Representative photos are shown (100X and 400X). b Number of CD68+, CD206+, CD86+, CD163+ and iNOS+ cells per low field in tissues from colon cancer patients at different stages. c PKN2 expression in normal colon tissue, polyp, adenoma and metastatic adenocarcinoma was measured using IHC. PKN2 expression scores were shown in (d). *, P < 0.05;***, P < 0.001 versusnormal colon. e Comparison of the percent of survival of patients with high level PKN2 (PKN2-High) and low level PKN2 (PKN2-Low) expression using the Kaplan-Meier method. f Number of CD68+, CD206+, CD86+, CD163+ and iNOS+ cells in tissues from colon cancer patients with different levels of PKN2 expression. ***, P < 0.001 versus PKN2-High

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Molecular Cancer

ISSN: 1476-4598