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Fig. 6 | Molecular Cancer

Fig. 6

From: HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Fig. 6

Thr-328 phosphorylation was required for the functional influence of PKM2 on glycolysis, proliferation and apoptosis of HCC cells. Compared with Huh7 cells transfected with wild-type PKM2, T328A PKM2 mutant significantly reduced (a) glucose consumption, (b) lactate production and (c) PK catalytic activity of Huh7 cells. Compared with Huh7 cells transfected with wild-type PKM2, Thr-328A mutated PKM2 significantly decreased the (d) proliferation and increased the (e) Caspase-3 activity and (f) apoptosis the of Huh7 cells. *, P < 0.05 by t test

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Molecular Cancer

ISSN: 1476-4598