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Table 2 Association of lncRNA AFAP1-AS1 expression with clinicopathologic features in TSCC patients

From: RETRACTED ARTICLE: Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway

Parameter

Total N = 103

LncRNA AFAP1-AS1

χ2

P

Low n = 42(%)

High n = 61(%)

Age (years)

 < 50

36

17(47.2)

19(52.7)

0.952

0.329

 ≥ 50

67

25(37.3)

42(62.7)

Gender

 Female

31

13(41.9)

18(58.1)

0.025

0.875

 Male

72

29(40.3)

43(59.7)

Betel-quid (BQ)a chewing habit

 No

38

20(52.6)

18(47.4)

3.504

0.061

 Yes

65

22(33.8)

43(66.2)

Tumor differentiation

 Well/moderate

69

33(47.8)

36(52.2)

4.301

0.038

 Poor

34

9(26.5)

25(73.5)

T classifcation

 T1-T2

61

30(49.2)

31(50.8)

4.375

0.036

 T3-T4 Clinical stage

42

12(28.6)

30(71.4)

(TNM)

 I-II

55

28(50.9)

27(49.1)

5.017

0.025

 III-IV

48

14(29.2)

34(70.8)

Depth of invasion

 <1 cm

46

25(50.0)

21(50.0)

6.339

0.012

 ≥1 cm

57

17(33.3)

40(66.7)

Relapse

 No

63

32(50.8)

31(49.2)

6.740

0.009

 Yes

40

10(25.0)

30(75.0)

Status

 Alive

66

32(48.5)

34(51.5)

4.52

0.033

 Dead

37

10(27.0)

27(73.0)

  1. aBetel quid (BQ, also called betel nut or areca nut) is one of the most commonly consumed psychoactive substances [62]. Long-term BQ chewing is strongly associated with oral precancerous conditions, including oral submucous fibrosis (OSF), and cancers of the oral cavity, pharynx, esophagus, and larynx [63,64,65]. Consequently, the International Agency for Research on Cancer categorized BQ as a Group 1 carcinogen in 2004 [66]. It is estimated that approximately 600 million people chew various types of BQ worldwide, predominantly in the countries of South and Southeast Asia [67]. In Mainland China, BQ chewing is mainly practiced in Hunan and Hainan provinces
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Molecular Cancer

ISSN: 1476-4598