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Fig. 8 | Molecular Cancer

Fig. 8

From: STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy

Fig. 8

HAGLROS promotes GC progression through mTOR-mediated autophagy inhibition. a Upon knockdown of HAGLROS by siRNAs, mTORC1 activity, including phosphorylation of both mTOR and downstream molecules, was analyzed in BGC-823 cell lines by Western blot. b Autophagy markers P62 and LC3 were measured by Western blot in BGC-823 cell lines with HAGLROS knockdown. c LC3-II punctuation was determined by BGC-823 cells co-transfected with GFP-LC3 plasmid and HAGLROS siRNAs by immunofluorescence assays. d and (e) BGC-823 cells were treated with the autophagic inhibitor 3-methyladenine (3-MA), and cell viability and migratory ability were measured by MTT assay (d) and (e) wound scratch assay. f Summary of the molecular mechanisms of HAGLROS in gastric cancer cells. *P < 0.05

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Molecular Cancer

ISSN: 1476-4598