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Fig. 7 | Molecular Cancer

Fig. 7

From: Long non-coding RNA XLOC_000647 suppresses progression of pancreatic cancer and decreases epithelial-mesenchymal transition-induced cell invasion by down-regulating NLRP3

Fig. 7

Inhibition of EMT-induced cells invasion regulated by XLOC_000647 overexpression was reversed by NLRP3 overexpression. a The vectors of pBABE + pENTER alone had no effect on the expression of NLRP3 (left). The protein levels of NLRP3 were up-regulated after transfected with NLRP3-pENTER in cells of XLOC_000647-stable overexpression compared with control cells (right). b The invasion of XLOC_000647-overexpressed cells transfected with NLRP3-pENTER when compared with the controls by transwell assays. Values represented the mean ± SD from three independent experiments. c Analysis of the E-cad and Vimentin protein levels in XLOC_000647-overexpressed cells transfected with NLRP3-pENTER and pENTER by western blot. NS (not significant). *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598