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Fig. 1 | Molecular Cancer

Fig. 1

From: Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer

Fig. 1

The clinical significance of cancer-related piRNAs in CRC. a Small RNA-seq revealed differentially expressed piRNAs between cancer and paired normal tissues (4 each) from the Mie cohort. The heatmaps maps illustrate the Z-score of each candidate piRNAs. b The expression of candidate piRNAs were validated in a subset of 20 cancer and paired normal mucosa (NM) specimens in Mie cohort. **P < 0.01, Wilcoxon paired test. The prognostic significance of piR-1245 was evaluated in colorectal cancer patients from TCGA datasets (c) and the clinical training cohort (Shanghai) (d) and the validation cohort (Okayama). e The OS (overall survival) analysis was performed by Kaplan–Meier test and the log-rank method (**P < 0.05, HR: Hazard Ratio)

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Molecular Cancer

ISSN: 1476-4598