Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Table 2 The comparison of 4 generation of EGFR TKIs

GN	RP	WT	Gene mutation			BI
GN	RP	WT	Exon 19/21	T790 M	C797S	BI
1st	Icotinib, Gefitinib, Erlotinib	+	+	–	–	–
2nd	Afatinib, Dacomitinib	++	+	+	–	+
3rd	Osimertinib, Rociletinib, Olmutinib, Nazartinib, Avitinib, ASP8273, PF-06747775, HS-10296	–	++	++	–	+
4th	EAI045	–	++	++	+	+

“+” stands for effective; “-” stands for ineffective; “GN” stands for generation; “RP” stands for representative; “BI” stands for binding irreversibly

ISSN: 1476-4598