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Fig. 1 | Molecular Cancer

Fig. 1

From: miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer

Fig. 1

miR-19b is regulated by the PI3K/AKT branch of the EGFR signaling pathway. a Heat map clustering of miRNAs that are dysregulated by the PI3K inhibitor LY294002. PC9 cells were treated with 20 μM LY294002 or DMSO control for 72 h and expression of 800 miRNAs was analyzed by NanoString using the nCounter Human miRNA Expression Assay Kit (n = 3). b Volcano plot of dysregulated miRNAs described in (A) using a cutoff ±0.4 log2 fold change (FC) (n = 3). c miR-19b expression level by real-time qPCR relative to RNU48 in EGFR mutant NSCLC cells treated with 1.25 μM gefitinib, 1.25 uM afatinib, 20 μM LY294002 and 10 μM U0126 for 72 h. Results are presented as mean ± SD (n = 3). ns, not significant. *, p < 0.05; **, p < 0.01; ***, p < 0.001

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